Stimulant Chemistry

Metabolic Pathways of Stimulants: Comparing 3-MMC, A-PVP and Modern Analogues Understanding the metabolic pathways of stimulants is crucial for predicting their duration, toxicity, detectability, and overall pharmacological behaviour. Among the most relevant research chemicals today are cathinones such as 3-MMC and pyrrolidine stimulants like A-PVP. Although both families share a beta-keto structure, their metabolic fates … Read more

The Chemical Foundations of Cathinones: Understanding 3-MMC and Related Stimulants Cathinones represent one of the most influential families in modern stimulant chemistry. Structurally related to amphetamines but defined by the presence of a beta‑keto group, cathinones have gained global attention due to compounds like 3‑MMC, 4‑MMC, and numerous analogues that continue to appear in the … Read more

Receptor Interactions of Modern Stimulants: DAT, NET and SERT Mechanisms Stimulant chemistry is defined by how molecules interact with three major monoamine transporters: the dopamine transporter (DAT), the norepinephrine transporter (NET), and the serotonin transporter (SERT). The balance of activity across these systems determines whether a stimulant feels euphoric, energetic, empathogenic, anxiogenic, or harsh. Research … Read more

Halogenation and Side‑Chain Engineering in Modern Stimulant Design Modern stimulant design is shaped by a combination of structural modification strategies, and two of the most influential are halogenation and side‑chain engineering. These approaches allow chemists to fine‑tune potency, transporter selectivity, metabolic stability, and overall pharmacological behaviour. Research chemicals such as 3-MMC, A-PVP, and their analogues … Read more