5F-MDMB

Information

5F-MDMB-PINACA (also known as 5F-ADB) is a synthetic cannabinoid belonging to the indazole-3-carboxamide family. It was first identified in 2014 and has been detected in various herbal mixtures sold as “synthetic cannabis.” The compound is a potent CB₁/CB₂ receptor agonist and is controlled in many countries due to its strong psychoactive and toxic effects.

Chemical Properties

Pharmacology and Effects

5F-MDMB-PINACA is a potent synthetic cannabinoid receptor agonist that mimics the effects of THC by strongly activating CB₁ and CB₂ receptors. It produces intense cannabis-like effects at very low doses and has been associated with severe toxicity and unpredictable physiological responses.

• Receptor targets: CB₁ and CB₂ cannabinoid receptors (full agonist)
• Potency: Very high (active at sub-milligram levels)
• Onset: Rapid (within minutes when inhaled)
• Duration: Typically 1–3 hours
• Reported effects: Euphoria, altered perception, sedation
• Adverse effects: Confusion, anxiety, tachycardia, vomitin

Risks and Side Effects

Severe and unpredictable toxicity; even small doses may cause serious adverse effects.

• Cardiovascular: Tachycardia, hypertension
• Neurological: Agitation, seizures
• Psychiatric: Psychosis, anxiety, panic
• Respiratory: Depression, difficulty breathing

Warning